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Cancer metastasis: selectable traits without genetic constraints.

Oliver G McDonald
Published in: Molecular & cellular oncology (2020)
Widely metastatic cancers progress rapidly despite sharing genetic drivers with the primary tumor that seeds them. Our recent work indicates that metastatic pancreatic cancers evolve unique metabolic adaptations that are not genetically encoded. These adaptations harness niche-refined nutrients, such as hepatic glucose, to fuel malignant metaboloepigenetic programs that support widespread metastatic outgrowth.
Keyphrases
  • squamous cell carcinoma
  • small cell lung cancer
  • genome wide
  • high intensity
  • papillary thyroid
  • copy number
  • public health
  • social media
  • healthcare
  • dna methylation
  • blood glucose
  • gene expression
  • young adults