Proton FLASH effects on mouse skin at different oxygen tensions.

Qixian ZhangLeo E GerweckEthan W CascioQingyuan YangPeigen HuangAndrzej NiemierkoAlejandro Bertolet Konrad Pawel NesterukAimee Louise McNamaraSchuemann Jan

Published in: Physics in medicine and biology (2023)

FLASH irradiation mitigated skin contraction by 15% compared to conventional dose rate irradiation. The epidermis thickness and collagen deposition at 75 days following 25 to 30 Gy exposure suggested a long-term protective function in the skin from FLASH irradiation. Providing the mice with oxygen or reducing the skin oxygen concentration removed the dose-rate-dependent difference in response.

Keyphrases

wound healing
soft tissue
type diabetes
optical coherence tomography
skeletal muscle
high fat diet induced
electron transfer