PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells.

Jessica ByerlyGwyneth Halstead-NusslochKoichi ItoIgor KatsyvHanna Y Irie

Published in: Breast cancer research : BCR (2016)

Enhanced PRKCQ/PKCθ expression can promote growth-factor-independent growth, anoikis resistance, and migration. PRKCQ critically regulates growth and survival of a subset of TNBC. Inhibition of PKCθ kinase activity may be an attractive therapeutic approach for TNBC, a subtype in need of improved targeted therapies.

Keyphrases

growth factor
breast cancer cells
protein kinase
binding protein
tyrosine kinase