Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia.

Giacomo CorleoneCristina SorinoMatteo CaforioStefano Di GiovenaleFrancesca De NicolaFrauke GoemanValentina BertainaAngela PitisciClelia CortileFranco LocatelliValentina FolgieroMaurizio Fanciulli

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our findings directly support the notion that productive enhancer engagement is a crucial determinant of the BCP-ALL and highlight the potential of enhancers as therapeutic targets in pediatric BCP-ALL.

Keyphrases

acute lymphoblastic leukemia
transcription factor
social media
binding protein
allogeneic hematopoietic stem cell transplantation
human health
risk assessment
young adults