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ACKR1+ Endothelial Cells Mediate Leukocyte Infiltration and Synergize with SFRP2/ASPN+ Fibroblasts to Promote Skin Fibrosis in Systemic Sclerosis.

Yan HuangWeilin PuLei WangQianqian MaYanyun MaQingmei LiuShuai JiangXiangyue ZhaoYuting ZhangQiuyu HeYulong TangJing LiuJui-Ming LinXiangguang ShiWenzhen TuYuanyuan ChenJinran LinYiyi GongWenyu WuJiucun Wang
Published in: The British journal of dermatology (2024)
Our results reveal that highly expressed ACKR1 in endothelial cells of fibrotic skin tissue promotes immune cell infiltration, and SFRP2/ASPN+ fibroblasts synergize to exacerbate skin fibrosis.
Keyphrases
  • systemic sclerosis
  • endothelial cells
  • interstitial lung disease
  • soft tissue
  • wound healing
  • extracellular matrix
  • high glucose
  • genome wide
  • idiopathic pulmonary fibrosis
  • rheumatoid arthritis
  • gene expression