Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations.
Charlotte AnderssonMaria Lukács KrogagerRegitze Kuhr SkalsEmil Vincent Rosenbaum AppelChristian Theil HaveNiels GrarupOluf PedersenJørgen L JeppesenOle Dyg PedersenMaria Helena Dominquez Vall-LamoraUlrik DixenThomas EngstrømNiels TønderDan M RodenSteen StenderGunnar H GislasonHenrik Enghusen-PoulsenTorben HansenLars KøberChristian Torp-PedersenPeter E WeekePublished in: PloS one (2019)
Young individuals presenting with CAD requiring surgical interventions had a higher genetic burden of SNPs relating to LDL-C and CAD (although the latter was statistically non-significant), compared with older individuals. However, the absolute difference was modest, suggesting that genetic screening can currently not be used as an effective prediction tool of when in life a person will develop CAD. Whether undiscovered genetic variants can still explain a "missing heritability" in early-onset CAD warrants more research.
Keyphrases
- coronary artery disease
- early onset
- cardiovascular events
- percutaneous coronary intervention
- genome wide
- coronary artery bypass grafting
- late onset
- physical activity
- middle aged
- copy number
- aortic stenosis
- gene expression
- cardiovascular disease
- risk factors
- case report
- community dwelling
- acute coronary syndrome
- left ventricular
- low density lipoprotein