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A Transmission-Based Dielectric Property Probe for Clinical Applications.

Paul MeaneyTomas RydholmHelena Brisby
Published in: Sensors (Basel, Switzerland) (2018)
We have developed a transmission-based, open-ended coaxial dielectric probe that can be used in clinical situations and overcomes many of the limitations related to the typical reflection-based dielectric probes. The approach utilizes the low profile, open-ended coaxial cables enabling clinicians to still probe relatively compact spaces. The sensing depth can be extended to as large as 1.5 to 2 cm compared with the more typical range of 0.3 mm for conventional probes and is dramatically less affected by measurement technique variability including poor sample contact and cable bending. As a precursor to an actual clinical implementation, we study the technique in a range of homogeneous liquids with substantially varying dielectric properties. The initial results demonstrate good agreement between the transmission-based probe and commercial, reflection-based probes and pave the way for more substantial clinical implementation.
Keyphrases
  • living cells
  • small molecule
  • fluorescent probe
  • quantum dots
  • primary care
  • healthcare
  • minimally invasive
  • single molecule
  • fluorescence imaging
  • palliative care
  • quality improvement
  • nucleic acid