Clinical Efficiency of Metagenomic Next-Generation Sequencing in Sputum for Pathogen Detection of Patients with Pneumonia According to Disease Severity and Host Immune Status.

Can ChangHuan WangLianjun ZhangJunling HaoXiaoning WangYaoyao WangFei QiJingwei LouJiangman ZhaoJunying Dong

Published in: Infection and drug resistance (2023)

mNGS is a complementary tool of CMT for detecting suspected pathogens for patients with lower respiratory infections. The interpretation of opportunistic pathogens identified by mNGS is challenging, and needs comprehensive consideration of sequencing data and clinical factors.

Keyphrases

gram negative
mycobacterium tuberculosis
pulmonary embolism
antimicrobial resistance
electronic health record
copy number
gene expression
machine learning
intensive care unit
multidrug resistant
antibiotic resistance genes
real time pcr
circulating tumor