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APOE ε4 influences medial temporal atrophy and tau deposition in atypical Alzheimer's disease.

Neha Atulkumar SinghNirubol TosakulwongJonathan Graff-RadfordMary M MachuldaNha Trang Thu PhamIrene SintiniStephen D WeigandChristopher G SchwarzMatthew L SenjemMinerva M CarrasquilloNilufer Ertekin-TanerClifford R JackVal J LoweKeith A JosephsJennifer L Whitwell
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
APOE ε4 influences patterns of neurodegeneration and tau deposition and was associated with more medial temporal involvement, although there is evidence that non-carriers may be catching up over time.
Keyphrases
  • cognitive decline
  • cerebrospinal fluid
  • high fat diet
  • mild cognitive impairment
  • type diabetes
  • adipose tissue