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Neutropenia and renal dysfunction due to intravesical cidofovir for virus-associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations.

Takuya ShimizuTadakazu KondoKana MatsumotoMasakatsu HishizawaKouhei YamashitaAkifumi Takaori-Kondo
Published in: Transplant infectious disease : an official journal of the Transplantation Society (2019)
We present a patient with virus-associated hemorrhagic cystitis who underwent kidney and allogenic hematopoietic stem cell transplantations (allo-HSCT). Six months post-allo-HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. This might cause prolonged neutropenia and nephrotoxicity, suggesting cidofovir absorption in the blood.
Keyphrases
  • hematopoietic stem cell
  • muscle invasive bladder cancer
  • urinary tract
  • chemotherapy induced
  • case report
  • oxidative stress
  • drug induced