Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1/2 MAP-Kinase inhibition.

Samia BedouheneFarida Moulti-MatiPham My-Chan DangJamel El Benna

Published in: Inflammopharmacology (2017)

Our data suggest that the anti-inflammatory properties of oleuropein and hydroxytyrosol are not only restricted to their ROS scavenging effect, but also involve the inhibition of two other major pro-inflammatory neutrophil functions.

Keyphrases

signaling pathway
anti inflammatory
cell proliferation
high glucose
cell death
diabetic rats
electronic health record
pi k akt
reactive oxygen species
big data
tyrosine kinase
protein kinase
stress induced