Head and voice tremor improving with immunotherapy in an anti-NF155 positive CIDP patient.
Cèlia PainousMª Ángeles López-PérezIsabel IllaLuis Antonio QuerolPublished in: Annals of clinical and translational neurology (2018)
Chronic inflammatory demyelinating polyradiculoneuropathy with NF155 antibodies (anti-NF155+) constitutes a specific chronic inflammatory demyelinating polyradiculoneuropathy subset with a high incidence of limb's tremor and poor response to conventional therapies. We report a patient with chronic inflammatory demyelinating polyradiculoneuropathy anti-NF155+ with a severe tremor involving limbs, head and voice that responded very well to rituximab. This response correlated with a sharp decrease in the anti-NF155 titers. This case is the first report associating head and voice tremor to chronic inflammatory demyelinating polyradiculoneuropathy, reinforces the hypothesis of the cerebellar origin of this tremor and provides indirect evidence that the antibodies may be the cause of the tremor in these patients.
Keyphrases
- deep brain stimulation
- oxidative stress
- parkinson disease
- signaling pathway
- lps induced
- pi k akt
- nuclear factor
- end stage renal disease
- optic nerve
- newly diagnosed
- chronic kidney disease
- ejection fraction
- drug induced
- diffuse large b cell lymphoma
- toll like receptor
- patient reported outcomes
- prognostic factors
- immune response
- optical coherence tomography
- hodgkin lymphoma
- patient reported
- chronic lymphocytic leukemia