Single-cell landscape analysis reveals systematic senescence in mammalian Down syndrome.
Yao ChenYanyu XiaoYanye ZhangRenying WangFeixia WangHuajing GaoYifeng LiuRunju ZhangHuiyu SunZiming ZhouSiwen WangKai ChenYixi SunMixue TuJingyi LiQiong LuoYiqing WuLinling ZhuYun HuangXiao SunGuoji GuoDan ZhangPublished in: Clinical and translational medicine (2023)
The findings from this study offer significant insights into the molecular alterations that occur in DS, shedding light on the pathological processes underlying this disorder. These results can potentially guide future research and treatment development for DS.