The dose-response effects of flurbiprofen, indomethacin, ibuprofen, and naproxen on primary skeletal muscle cells.

Brandon M RobertsAlyssa V GeddisRonald W Matheny

Published in: Journal of the International Society of Sports Nutrition (2024)

Our findings suggest that indomethacin, at high concentrations, may detrimentally affect myoblast proliferation and differentiation via an AKT-dependent mechanism, and thus provide new understanding of NSAIDs' effects on skeletal muscle cell development.

Keyphrases

skeletal muscle
signaling pathway
induced apoptosis
insulin resistance
cell cycle arrest
single cell
cell proliferation
cell therapy
pi k akt
endoplasmic reticulum stress
oxidative stress
adipose tissue
type diabetes
metabolic syndrome
mesenchymal stem cells
postoperative pain