A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA.
Yangchun FanXin JiangJie CheMingfeng LiXuejuan ZhangDaojiang GaoJian BiZhanglei NingPublished in: Molecules (Basel, Switzerland) (2022)
Thiodiglycolic acid (TDGA) is a biomarker for monitoring vinyl chloride exposure. Exploring a facile, rapid and precise analysis technology to quantify TDGA is of great significance. In this research, we demonstrate a fluorescent sensor based on dual-emissive UiO-66 for TDGA detection. This ratiometric fluorescent material named C460@Tb-UiO-66-(COOH) 2 was designed and synthesized by introducing organic dye 7-diethylamino-4-methylcoumarin (C460) and Tb 3+ into UiO-66-(COOH) 2 . The as-obtained C460@Tb-UiO-66-(COOH) 2 samples showed highly selective recognition, excellent anti-interference and rapid response characteristics for the recognition of TDGA. The detection limit is 0.518 mg·mL -1 , which is much lower than the threshold of 20 mg·mL -1 for a healthy person. In addition, the mechanism of TDGA-induced fluorescence quenching is discussed in detail. This sensor is expected to detect TDGA content in human urine.
Keyphrases
- quantum dots
- sensitive detection
- loop mediated isothermal amplification
- metal organic framework
- energy transfer
- mycobacterium tuberculosis
- living cells
- endothelial cells
- label free
- highly efficient
- fluorescent probe
- diabetic rats
- drug induced
- induced pluripotent stem cells
- hydrogen peroxide
- nitric oxide
- high resolution
- stress induced