Establishment of an animal model of immune-related adverse events induced by immune checkpoint inhibitors.

Yuan MengYingge LvMeng ShenWenwen YuYumeng LiuTing LiuGen LiuShiya MaZhenzhen HuiXiubao RenLiang Liu

Published in: Cancer medicine (2024)

The irAE-related animal model was successfully established in BALB/c mice using a combination of PD-1 and CTLA-4 inhibitors through multiple administrations with clinical translational value and practical. This model offers valuable insights into irAE mechanisms for further investigation.

Keyphrases

type diabetes
high fat diet induced
insulin resistance
drug induced