Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS.
Maura ManionThomas UldrickMark N PolizzottoVirginia SheikhGregg RobyKathryn LurainDorinda MetzgerJoAnn M MicanAlice PauAndrea LiscoElizabeth LaidlawDima A HammoudDenise WhitbyRobert YarchoanIrini SeretiPublished in: Open forum infectious diseases (2018)
Corticosteroid use was associated with development of Kaposi's sarcoma or multicentric Castleman disease in 3 patients with mycobacterial immune reconstitution inflammatory syndrome (IRIS) treated with corticosteroids. Monitoring for development of Kaposi's sarcoma and alternative treatment may be beneficial for patients with IRIS, especially in the presence of preexisting co-infection with Kaposi's sarcoma-associated herpesvirus.