Ubiquitous mitochondrial creatine kinase promotes the progression of gastric cancer through a JNK-MAPK/JUN/HK2 axis regulated glycolysis.
Yushuai MiQuanhui LiBingtian LiuDehai WangZiping LiuTianshi WangYuan WangYifeng ZangYan ZhouYugang WenYinlu DingPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)
uMtCK could serve as a novel independent prognostic biomarker as well as potential therapeutic target for GC patients, particularly for GC patients with an advanced UICC stage and tumor recurrence.
Keyphrases
- end stage renal disease
- signaling pathway
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- cell death
- transcription factor
- cell proliferation
- climate change
- mass spectrometry
- pi k akt
- patient reported outcomes
- free survival
- human health
- endothelial cells
- patient reported
- simultaneous determination
- liquid chromatography