Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll-Like receptor 4.
Kathleen R HeimMelissa J MullaJulie A PotterChristina S HanSeth GullerVikki M AbrahamsPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
The findings from this study indicate a novel mechanism by which hyperglycemia may impact trophoblast function, early placentation, and ultimately, pregnancy outcome.