Synthesis of gem-Difluorinated Hydroxypyrrolidines.
Oleg V FedorovMarina I StruchkovaAlexander D DilmanPublished in: The Journal of organic chemistry (2017)
A method for the synthesis of 3-hydroxy-4,4-difluoropyrrolidines from α,α-difluoro-β-bromoketones is described. The reaction involves methylenation of the carbonyl group with tetrahydrothiophenium ylide followed by coupling with primary amines.
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