Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders.

Markos TesfayePiotr JaholkowskiAlexey A ShadrinDennis van der MeerGuy F L HindleyBørge HolenNadine ParkerPravesh ParekhViktoria BirkenæsZillur RahmanShahram BahramiGleda KutrolliOleksandr FreiSrdjan DjurovicAnders M DaleOlav B SmelandKevin S O'ConnellOle Andreas Andreassen

Published in: Psychiatry and clinical neurosciences (2024)

Anxiety is highly polygenic phenotype with extensive genetic overlap with psychiatric disorders, and we identified novel loci for anxiety implicating new molecular pathways. The shared genetic architecture may underlie the extensive cross-disorder comorbidity of anxiety, and the identified molecular underpinnings may lead to potential drug targets.

Keyphrases

genome wide
sleep quality
copy number
dna methylation
gene expression
genome wide association study
climate change
adverse drug