Immunosuppression with cyclosporine versus tacrolimus shows distinctive nephrotoxicity profiles within renal compartments.

Hasan Demirci Suncica PopovicCarsten DittmayerDuygu Elif YilmazIsmail Amr El-ShimyMichael MüllederChristian HinzeMingzhen SuPhilipp MertinsMarieluise KirchnerBilgin OsmanodjaAlexander PaliegeKlemens BuddeKerstin AmannPontus B PerssonKerim MutigSebastian Bachmann

Published in: Acta physiologica (Oxford, England) (2024)

We conclude that pathogenetic alterations in the renal compartments are specific for either treatment. Considering translation to the clinical setting, CNI choice should reflect individual risk factors for renal vasculature and tubular epithelia. As a step in this direction, we share protein signatures identified from multiomics with potential pathognomonic relevance.

Keyphrases

genome wide
gene expression
combination therapy
protein protein
binding protein
human health
decision making