Phenolic Profiling and Therapeutic Potential of Certain Isolated Compounds from Parkia roxburghii against AChE Activity as well as GABAA α5, GSK-3β, and p38α MAP-Kinase Genes.
Heba A El GizawyHeba M Abo-SalemAli A AliMohammed Abdalla HusseinPublished in: ACS omega (2021)
Parkia roxburghii belongs to the family Mimosaceae; it has been used since ancient times as a cure for different health complications; such as inflammatory and gynecological diseases and hemiplegia. In this investigation, a reversed-phase-high-performance liquid chromatography (RP-HPLC) profile was carried out for P. roxburghii; also, the isolated bioactive compounds including quercetin, catechin, and biochaninA were individually and/or in combination investigated for their inhibitory effects on scopolamine-induced memory impairments in mice, implying that they have the ability to reduce the neurodegenerative effects of scopolamine and thus could be employed as a more effective therapeutic agent in the treatment of Alzheimer's disease (AD) in humans. The possible interactions of Parkia flavonoids with acetylcholinesterase (AChE), γ-aminobutyric acid A receptor, alpha5 (GABAA α5), glycogen synthase kinase-3 (GSK-3), p38 mitogen-activated protein kinase (p38MAP-kinase), signal-regulated kinase (ERK), and protein-serine/threonine kinase (Akt) were then determined using molecular docking.
Keyphrases
- protein kinase
- high performance liquid chromatography
- molecular docking
- signaling pathway
- tyrosine kinase
- cell proliferation
- mass spectrometry
- public health
- ms ms
- simultaneous determination
- tandem mass spectrometry
- type diabetes
- molecular dynamics simulations
- working memory
- small molecule
- single cell
- risk factors
- adipose tissue
- risk assessment
- health information
- binding protein
- metabolic syndrome
- atomic force microscopy
- drug induced
- protein protein
- mild cognitive impairment
- high speed
- liquid chromatography