Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies.
Bernard A FoxWalter J UrbaShawn M JensenDavid B PageBrendan D CurtiRachel E SanbornRom S LeidnerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
The authors of a recent study identified non-canonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens.