Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity.

Samantha Slight-WebbRufei LuLauren L RitterhouseMelissa E MunroeHolden T MaeckerCharles G FathmanPaul J UtzJoan T MerrillJoel M GuthridgeJudith A James

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

ANA-positive healthy individuals exhibit dysregulation in multiple immune pathways yet differ from SLE patients by the absence of elevated IFNs, BLyS, IL-12p40, and stem cell factor/c-Kit ligand. Further, severely decreased levels of IL-1Ra in SLE patients compared with ANA-positive individuals may contribute to disease development. These results highlight the importance of IFN-related pathways and regulatory elements in SLE pathogenesis.

Keyphrases

end stage renal disease
systemic lupus erythematosus
stem cells
ejection fraction
chronic kidney disease
newly diagnosed
disease activity
peritoneal dialysis
prognostic factors
rheumatoid arthritis
dendritic cells
bone marrow