Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score.

Laura BoucaiVenkatraman SeshanMichelle WilliamsJeffrey A KnaufMahesh SaqcenaRonald A GhosseinJames A Fagin

Published in: The Journal of clinical endocrinology and metabolism (2022)

Enrichment for RAS signatures, key genes involved in cell polarity and specific miRs targeting the TGFβ-SMAD pathway define 2 subtypes of BRAF-mutant PTCs with distinct clinical characteristics and prognosis.

Keyphrases

papillary thyroid
wild type
lymph node metastasis
transforming growth factor
epithelial mesenchymal transition
single cell
cell therapy
squamous cell carcinoma
cancer therapy
gene expression
stem cells