Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway.

Maozhang LiGuangwei BaiYi CenQitong XieJiahong ChenJia ChenQingbiao ChenWei-De ZhongXiaobo Zhou

Published in: Journal of translational medicine (2023)

HOXC13 regulates PCa progression by mediating the DNA damage-induced cGAS/STING/IRF3 pathway and remodels TIME through regulation of the transcription of the immune factors IFN-β, CCL2, CCL5 and CXCL10.

Keyphrases

dna damage
prostate cancer
dendritic cells
oxidative stress
dna repair
liver injury
drug induced
liver fibrosis
diabetic rats
radical prostatectomy
signaling pathway
immune response
high glucose
endothelial cells