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Temporal serum neurofilament light chain concentrations in sheep inoculated with the agent of classical scrapie.

Quazetta BrownEric NicholsonChong WangJustin J GreenleeHannah SegerSusan VenezianoEric D Cassmann
Published in: PloS one (2024)
Serum Nf-L concentrations in the cohort of sheep increased as disease progressed; however, serum Nf-L did not increase during the presymptomatic window. The levels increased substantially throughout the final 10% of the animals' scrapie incubation period when other clinical signs were present. Serum Nf-L is not a reliable biomarker for pre-clinical detection of scrapie.
Keyphrases
  • signaling pathway
  • lps induced
  • oxidative stress
  • pi k akt
  • nuclear factor
  • inflammatory response
  • cell proliferation
  • toll like receptor
  • real time pcr