Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial.
Jen-Tsan Ashley ChiPao-Hwa LinVladimir TolstikovLauren E HowardEmily Y ChenValerie BussbergBennett GreenwoodNiven R NarainMichael A KiebishStephen J FreedlandPublished in: Prostate cancer and prostatic diseases (2022)
These results suggest a potential association of ketogenesis and TCA metabolites with slower PC growth and conversely glycolysis with faster PC growth. The link of high ketone bodies with longer PSADT supports future studies of ketogenic diets to slow PC growth.