Role of HLA genes in development of HLA-alloimmunization in blood recipients.
E V ButinaF S SherstnevO D MaksimovA V YovdiyIgor ParamonovPublished in: Klinicheskaia laboratornaia diagnostika (2022)
A genetically determined predisposition to the development of HLA-alloimmunization as a result of blood transfusions is associated with the presence of HLA-alleles DRB1*04, DQA1*03:01, DQA1*05:01 and HLA-haplotype DRB1*04-DQA1*03:01-DQB1*03:02 in the genotypes of recipients. The risk of antibody production is reduced in patients with HLA-alleles DRB1*16, DQA1*01:02, DQB1*05:02 and HLA-haplotype DRB1*16-DQA1*01:02-DQB1*05:02.