HER2/ERBB2 copy number analysis by targeted next-generation sequencing in breast cancer.

Daniel XiaFrank KuoMelissa HughesNeal LindemanDanielle ManningJanet FilesSarah StraussGreg KirknerAyesha Mohammed-AbreuEric WinerSara M TolaneyNancy U LinDeborah A Dillon

Published in: American journal of clinical pathology (2024)

Copy number data from our NGS panel strongly correlate with HER2 status. Using a stringent cutoff, ERBB2 log2 ratio accurately predicts HER2 positivity with high specificity. The NGS CN assessment may have utility in determining HER2 status in certain clinical settings.

Keyphrases

copy number
mitochondrial dna
genome wide
tyrosine kinase
dna methylation
electronic health record
cancer therapy
machine learning
deep learning
structural basis
cell free