Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection.
David T HuangDonald M YealyMichael R FilbinAaron M BrownChung-Chou H ChangYohei DoiMichael W DonninoJonathan FineMichael J FineMichelle A FischerJohn M HolstPeter C HouJohn A KellumFeras KhanMichael C KurzShahram LotfipourFrank LoVecchioOctavia M Peck-PalmerFrancis PikeHeather PruntyRobert L SherwinLauren SoutherlandThomas TerndrupLisa A WeissfeldJonathan YabesDerek C Angusnull nullPublished in: The New England journal of medicine (2018)
The provision of procalcitonin assay results, along with instructions on their interpretation, to emergency department and hospital-based clinicians did not result in less use of antibiotics than did usual care among patients with suspected lower respiratory tract infection. (Funded by the National Institute of General Medical Sciences; ProACT ClinicalTrials.gov number, NCT02130986 .).