Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.

Qian ChenJiexing HeHaihua LiuQiuyu HuangShuoshi WangAilan YinShuying ChenXinyang ShenYanxuan XiaoHaoyue HuJiayi JiangWenqian ChenSong WangZhenqin HuangJiaqi LiYou PengXiaocong WangXinping YangZhijian WangMei Zhong

Published in: Journal of translational medicine (2023)

Herein, results in the present study supported that TDRKH-AS1 in sEVs isolated from oxidative stress trophoblast may be implicated in the pathogenesis of PE via inducing pyroptosis and aggravating endothelial dysfunction.

Keyphrases

oxidative stress
endothelial cells
nlrp inflammasome
early onset
dna damage
long non coding rna
pregnant women
high glucose
induced apoptosis