Replication study of THADA rs13429458 variant with PCOS susceptibility and its related traits in Indian women.

Roshan DadachanjiDivya SawantAnushree Patil Srabani Mukherjee

Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2021)

To our knowledge, this is the first study to demonstrate that although this polymorphism does not alter PCOS susceptibility, it favorably impacts glucose metabolism and hyperandrogenism in Indian women with PCOS only. This study highlights that genetic predisposition markers for PCOS may differ with ethnicity and phenotypic variations.

Keyphrases

polycystic ovary syndrome
healthcare
insulin resistance
type diabetes
genome wide
metabolic syndrome
pregnant women
dna methylation
skeletal muscle
pregnancy outcomes
drug induced