Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling.
Mehreen SoomroMichael StadlerNick DandJames BluettDeepak JadonFarideh Jalali-NajafabadiMichael DuckworthPauline HoHelena Marzo-OrtegaPhilip S HelliwellAnthony W RyanDavid KaneEleanor KorendowychMichael A SimpsonJonathan PackhamRoss McManusCem GabayCéline LamacchiaMichael J NissenMatthew A BrownSuzanne M M VerstappenTjeerd Van StaaJonathan N BarkerCatherine H Smithnull nullnull nullOliver FitzGeraldNeil McHughRichard B WarrenJohn BowesAnne BartonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Key biologic pathways associated with the development of PsA were identified, but the investigation of risk classification revealed modest utility in the available data sets, possibly because many of the PsC patients included in the present study were receiving treatments that are also effective in PsA. Future predictive models of PsA should be tested in PsC patients recruited from primary care.