RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging.

Margie N SuttonSeth T GammonRiccardo MuzzioliFederica PisaneschiBhasker RadaramPing YangDavid Piwnica-Worms

Published in: Molecular imaging and biology (2021)

These data provide a novel approach using NIR-labeled human serum albumin to identify and monitor RAS-driven tumors as well as evaluate the on-target efficacy in vivo of inhibitors, such as ARS-1620.

Keyphrases

fluorescence imaging
photodynamic therapy
wild type
human serum albumin
social media
electronic health record
pet imaging
fluorescent probe
drug delivery
deep learning
artificial intelligence
pet ct