Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signaling.

Zhirui ZhangWei WuHao JiaoYuzhong ChenXiaojun JiJing CaoFangzhou YinKaiyong Yang

Published in: British journal of pharmacology (2022)

Taken together, SQLE serves as a novel oncogene in HCC development by activating TGF-β/SMAD signaling, and targeting SQLE could be useful in drug development and therapy for HCC.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
transcription factor
cancer therapy
drug delivery