Pharmacokinetics of an intravenous bolus dose of clonidine in children undergoing surgery.

Bettina Nygaard Nielsen Brian Joseph AndersonLars FalconSteen W HennebergTorsten LauritsenErik LomsteinMogens Ydemann Arash Afshari

Published in: Paediatric anaesthesia (2020)

Pharmacokinetic parameter estimates were similar for children undergoing general surgery and cardiac surgery given a single dose of intravenous clonidine. These results indicated that no dose reduction is needed in children aged 1 to <2 years compared with those 2-5 years, which was supported by pharmacodynamic observations.

Keyphrases

cardiac surgery
young adults
high dose
minimally invasive
acute kidney injury
coronary artery bypass
low dose
coronary artery disease
acute coronary syndrome
percutaneous coronary intervention