Dioxygen Binding Is Controlled by the Protein Environment in Non-heme Fe II and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme.

Shobhit S ChaturvediMidhun George ThomasSimahudeen Bathir Jaber Sathik RifayeeWalter WhiteJon WildeyCait WarnerChristopher J SchofieldJian HuRobert P HausingerTatayana G Karabencheva-ChristovaChristo Z Christov

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2023)

Invited for the cover of this issue are Christo Z. Christov and co-workers at Michigan Technological University, University of Oxford, and Michigan State University. The image depicts the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE) and changes in the enzymes' conformations upon binding. Read the full text of the article at 10.1002/chem.202300138.

Keyphrases

dna methylation
binding protein
dna binding
deep learning
gene expression
transcription factor