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Telomere-specific chromatin capture using a pyrrole-imidazole polyamide probe for the identification of proteins and non-coding RNAs.

Satoru IdeAsuka SasakiYusuke KawamotoToshikazu BandoHiroshi SugiyamaKazuhiro Maeshima
Published in: Epigenetics & chromatin (2021)
PI-PRICh reproducibly identified both the protein and RNA components of telomeric chromatin when targeting telomere repeats. PI polyamide is a promising alternative to simultaneously isolate associated proteins and RNAs of sequence-specific chromatin regions under native conditions, allowing better understanding of chromatin organization and functions within the cell.
Keyphrases
  • dna damage
  • gene expression
  • transcription factor
  • genome wide
  • single cell
  • dna methylation
  • stem cells
  • oxidative stress
  • quantum dots
  • drug delivery
  • mesenchymal stem cells
  • binding protein
  • nucleic acid
  • fluorescent probe