Shaping the course of early-onset Parkinson's disease: insights from a longitudinal cohort.

Roberta BovenziMatteo ContiGiulia Rebecca DegoliRocco CerroniClara SimonettaClaudio LiguoriChiara SalimeiAntonio PisaniMariangela PierantozziAlessandro StefaniNicola Biagio MercuriTommaso Schirinzi

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)

We shaped EOPD course, modelling a "brain-first" PD subtype, slowly progressive, with non-linear dopaminergic requirement. Major burden mostly resulted from motor fluctuations, neuropsychiatric complications, sexual and marital complaints, with a considerable gender-effect.

Keyphrases

early onset
late onset
mental health
multiple sclerosis
risk factors
white matter
resting state
functional connectivity
cerebral ischemia
brain injury