A novel mouse model of human prostate cancer to study intraprostatic tumor growth and the development of lymph node metastases.
Johannes LinxweilerChristina KörbelAndreas MüllerMarkus HammerChristian VeithRainer M BohleMichael StöckleKerstin JunkerMichael D MengerMatthias SaarPublished in: The Prostate (2018)
By using different monolayer and 3D spheroid cell cultures in an orthotopic xenograft model, we established an innovative, versatile in vivo model of prostate cancer, which enables the study of both intraprostatic tumor growth as well as metastatic spread to regional lymph nodes. HrUS and MRI are feasible tools to monitor tumor growth and the development of lymph node metastases while these cannot be visualized by μCT.
Keyphrases
- lymph node
- prostate cancer
- mouse model
- neoadjuvant chemotherapy
- endothelial cells
- sentinel lymph node
- squamous cell carcinoma
- small cell lung cancer
- magnetic resonance imaging
- computed tomography
- single cell
- stem cells
- cell therapy
- bone marrow
- radiation therapy
- diffusion weighted imaging
- mesenchymal stem cells
- dual energy