Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions.

MLH1-PMS2 suppresses divergent repeat-mediated deletions (RMDs).MLH1-PMS2 promotes polar resolution of sequence divergence.Several mutants of MLH1-PMS2 affect both aspects of RMDs.Some MLH1-PMS2 mutants affect only one aspect of RMDs.Suppression of RMDs vs. polar resolution of divergence appear distinct.