Identification of adipose tissue transcriptomic memory of anorexia nervosa.

Rizaldy C ZapataChanond A NasamranDaisy R Chilin-FuentesStephanie C DulawaOlivia Osborn

Published in: Molecular medicine (Cambridge, Mass.) (2023)

We demonstrated the presence of peristent changes in the adipose tissue transcriptome in the ABA mice after weight restoration. Despite being on the opposite spectrum of weight perturbations, majority of the transcriptomic memory genes of under- and over-nutrition did not overlap, suggestive of the different mechanisms involved in these extreme nutritional statuses.

Keyphrases

adipose tissue
anorexia nervosa
single cell
rna seq
physical activity
insulin resistance
body mass index
weight loss
working memory
bioinformatics analysis
genome wide
high fat diet
weight gain
high fat diet induced
body weight
gene expression
climate change
type diabetes