Polypharmacy in atrial fibrillation: A prospective analysis of mortality and ischemic stroke using the Clinical Practice Research Datalink.
Natasha SlaterSimon WhiteMartin FrisherPublished in: Journal of arrhythmia (2023)
Polypharmacy was associated with an increased risk of death during follow-up, but not ischemic stroke, in individuals with AF. The effects of comorbidity and other confounding factors were reduced by using PSM. This study focused on the overall medication burden; however, further research is needed to identify which specific medications in polypharmacy regimens increase the risk of mortality in AF. These findings could inform prescribing practices in the future.
Keyphrases
- atrial fibrillation
- adverse drug
- oral anticoagulants
- left atrial
- catheter ablation
- primary care
- clinical practice
- left atrial appendage
- direct oral anticoagulants
- cardiovascular events
- healthcare
- risk factors
- heart failure
- percutaneous coronary intervention
- current status
- cardiovascular disease
- drug induced
- left ventricular
- mitral valve
- venous thromboembolism