The Mechanism of Dendrobium officinale as a Treatment for Hyperlipidemia Based on Network Pharmacology and Experimental Validation.

Lin-Zi LiHui-Ying WangJia-Hui HuangKun LiuXiao-Jie FengXi-Ming WangLi-Jie ZhuXing-Lishang HeXiang ZhengHai-Long LiYing-Jie DongBo LiHan-Song WuNing-Hua Jiang Gui-Yuan Lv Su-Hong Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

In summary, the biological targets of the main bioactive compounds in DO were found to distribute across multiple metabolic pathways. These findings suggest that a mutual regulatory system consisting of multiple components, targets, and pathways is a likely mechanism through which DO may improve hyperlipidemia. Validation experiments indicated that DO may treat hyperlipidemia by affecting NAFLD-related signaling pathways.

Keyphrases

high fat diet
signaling pathway
high fat diet induced
transcription factor
insulin resistance
pi k akt
combination therapy
skeletal muscle
epithelial mesenchymal transition
metabolic syndrome
replacement therapy
drug induced
endoplasmic reticulum stress
smoking cessation