Inclusion of deuterated glycopeptides provides increased sequence coverage in hydrogen/deuterium exchange mass spectrometry analysis of SARS-CoV-2 spike glycoprotein.
Christopher A HaynesTheodore R KeppelBetlehem MekonnenSarah H OsmanYu ZhouAdrian R WoolfittJakub BaudysJohn R BarrDongxia WangPublished in: Rapid communications in mass spectrometry : RCM (2024)
Inclusion of deuterated glycopeptides improves the analysis of the conformational dynamics of glycoproteins such as viral surface antigens and cellular receptors.
Keyphrases
- sars cov
- mass spectrometry
- respiratory syndrome coronavirus
- liquid chromatography
- molecular dynamics
- molecular dynamics simulations
- single molecule
- dendritic cells
- capillary electrophoresis
- high resolution
- high performance liquid chromatography
- affordable care act
- gas chromatography
- healthcare
- amino acid
- immune response
- coronavirus disease
- tandem mass spectrometry
- ms ms