Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy.
Rasmus K JensenFrederic JabsMichaela MieheBrian MølgaardWolfgang PfütznerChristian MöbsEdzard SpillnerGregers Rom AndersenPublished in: Allergy (2020)
Our data reveal the first structures of intact IgE suggesting that the IgE Fab is fixed relative to the Fc. Furthermore, we provide a structural rationale for the inhibitory mechanism of ligelizumab.