Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy.

Rasmus K JensenFrederic JabsMichaela MieheBrian MølgaardWolfgang Pfützner Christian Möbs Edzard Spillner Gregers Rom Andersen

Published in: Allergy (2020)

Our data reveal the first structures of intact IgE suggesting that the IgE Fab is fixed relative to the Fc. Furthermore, we provide a structural rationale for the inhibitory mechanism of ligelizumab.

Keyphrases

electron microscopy
high resolution
clinical trial
genome wide
single cell
gene expression
machine learning
dna methylation
artificial intelligence