European Respiratory Society guidelines for the Diagnosis and Management of Pulmonary Alveolar Proteinosis.
Cormac Mc CarthyFrancesco BonellaMarissa O'CallaghanClairelyne DupinTiago M AlfaroYunus Emre KundakciRaphael BorieIlaria CampoVincent CottinAurelie FabreMatthias GrieseAlice HadchouelStéphane JouneauMaria KokosiEffrosyni ManaliHelmut ProschBruce TrapnellMarcel VeltkampTisha WangIngrid ToewsAlexander G MathioudakisElizabeth BendstrupPublished in: The European respiratory journal (2024)
The diagnosis of PAP is based on CT and BAL cytology or lung histology, whereas diagnosis of specific PAP-causing diseases requires GM-CSF antibody testing or genetic analysis. There are several therapies including WLL and augmentation therapy with GM-CSF available to treat PAP, but supporting evidence is still limited.