Urinary Metabolomic Profiling Reveals Biological Pathways and Predictive Signatures Associated with Childhood Asthma.

Shuxian LiJinling LiuJunfen ZhouYingshuo WangFang JinXiaoyang ChenJun Yang Zhimin Chen

Published in: Journal of asthma and allergy (2020)

Our study revealed significant changes in the urine metabolome of asthma patients. Several perturbed pathways (eg, sphingolipid metabolism and citric acid cycle) may be related to asthma pathogenesis, and 2-hydroxybutanoic acid could serve as a potential biomarker for asthma diagnosis.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
end stage renal disease
single cell
newly diagnosed
ejection fraction
cystic fibrosis
gene expression
young adults
genome wide
patient reported